MIT SRP Labs Collaborate on Study of NDMA SusceptibilityBy Bevin P. Engelward
MIT SRP Program Director
Sep 20, 2021
Congratulations to Amanda L. Armijo, Pennapa Thongararm, Bogdan I. Fedeles, Judy Yau, Jennifer E. Kay, Joshua J. Corrigan, Marisa Chancharoen, Supawadee Chawanthayatham, Leona D. Samson, Sebastian E. Carrasco, Bevin P. Engelward, James G. Fox, Robert G. Croy and John M. Essigmann on their recent publication in NAR Cancer in 2023! In this work, the authors show that there is a distinct mutation pattern when mice are exposed to N-nitrosodimethylamine, a DNA methylating agent. This pattern is strikingly similar to the pattern of mutations in tumors from patients treated with a related DNA methylating agent, temozolomide. The pattern appears to be driven largely by O6-methylguanine, a damaged base that readily mispairs with thymine to induce GC to AT mutations.