PUBLICATIONS

Implications of an epidemiological study showing an association between in utero NDMA exposure and childhood cancer
Engelward BP
Environ Mol Mutagen. 2021 Jun;62(5):288-292. doi: 10.1002/em.22434
PMID: 33963777
See also our blog and an NIEHS news article.

Global Cancer Risk From Unregulated Polycyclic Aromatic Hydrocarbons
Kelly JM, Ivatt PD, Evans MJ, Kroll JH, Hrdina AIH, Kohale IN, White FM, Engelward BP, Selin NE
Geohealth. 2021 Sep 1;5(9):e2021GH000401. doi: 10.1029/2021GH000401
PMID: 34589640
MIT News. Study: Global cancer risk from burning organic matter comes from unregulated chemicals
Environmental Health News. We’re miscalculating the cancer risk from a massive class of chemicals: MIT Study

Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice
Kay JE, Corrigan JJ, Armijo AL, Nazari IS, Kohale IN, Torous DK, Avlasevich SL, Croy RG, Wadduwage DN, Carrasco SE, Dertinger SD, White FM, Essigmann JM, Samson LD, Engelward BP
Cell Rep. 2021 Mar 16;34(11):108864. doi: 10.1016/j.celrep.2021.108864
PMID: 33730582
MIT News. Study: An enzyme that dictates cells’ response to a probable carcinogen.
NIEHS Paper of the Month
In Genetic Engineering and Biotechnology News (GEN)

A case study in participatory science with mutual capacity building between university and tribal researchers to investigate drinking water quality in rural Maine
Segev T, Harvey AP, Ajmani A, Johnson C, Longfellow W, Vandiver KM, Hemond H
Environ Res. 2021 Jan;192:110460. doi: 10.1016/j.envres.2020.110460
PMID: 33217437

An Organic Chemist’s Guide to N-Nitrosamines: Their Structure, Reactivity, and Role as Contaminants
Beard JC, Swager TM
J Org Chem. 2021 Feb 5;86(3):2037-2057. doi: 10.1021/acs.joc.0c02774
PMID: 33474939

Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks
Kohale IN, Burgenske DM, Mladek AC, Bakken KK, Kuang J, Boughey JC, Wang L, Carter JM, Haura EB, Goetz MP, Sarkaria JN, White FM
Cancer Res. 2021 Jul 15;81(14):3930-3941. doi: 10.1158/0008-5472.CAN-21-0214
PMID: 34016623

CometChip enables parallel analysis of multiple DNA repair activities
Ge J, Ngo LP, Kaushal S, Tay IJ, Thadhani E, Kay JE, Mazzucato P, Chow DN, Fessler JL, Weingeist DM, Sobol RW, Samson LD, Floyd SR, Engelward BP
DNA Repair (Amst). 2021 Oct;106:103176. doi: 10.1016/j.dnarep.2021.103176
PMID: 34365116

Andrographolide, an Antioxidant, Counteracts Paraquat- Induced Mutagenesis in Mammalian Cells
Tajai P, Suriyo T, Rangkadilok N, Fedeles B, Essigmann JM, Satayavivad J
Asian Pac J Cancer Prev. 2021 Feb 1;22(S1):3-8. doi: 10.31557/APJCP.2021.22.S1.3
PMID: 33576206

CometChip analysis of human primary lymphocytes enables quantification of inter-individual differences in the kinetics of repair of oxidative DNA damage
Ngo LP, Kaushal S, Chaim IA, Mazzucato P, Ricciardi C, Samson LD, Nagel ZD, Engelward BP
Free Radic Biol Med. 2021 Oct;174:89-99. doi: 10.1016/j.freeradbiomed.2021.07.033
PMID: 34324980

High-Density, Targeted Monitoring of Tyrosine Phosphorylation Reveals Activated Signaling Networks in Human Tumors
Stopfer LE, Flower CT, Gajadhar AS, Patel B, Gallien S, Lopez-Ferrer D, White FM
Cancer Res. 2021 May 1;81(9):2495-2509. doi: 10.1158/0008-5472.CAN-20-3804
PMID: 33509940

A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures
Buick JK, Williams A, Meier MJ, Swartz CD, Recio L, Gagné R, Ferguson SS, Engelward BP, Yauk CL
Front Public Health. 2021 Aug 18;9:694834. doi: 10.3389/fpubh.2021.694834
PMID: 34485225

Fluorescence Sheds Light on DNA Damage, DNA Repair, and Mutations
Owiti NA, Nagel ZD, Engelward BP
Trends Cancer. 2021 Mar;7(3):240-248. doi: 10.1016/j.trecan.2020.10.006
PMID: 33203608

Analysis of mutations in tumor and normal adjacent tissue via fluorescence detection
Kay JE, Mirabal S, Briley WE, Kimoto T, Poutahidis T, Ragan T, So PT, Wadduwage DN, Erdman SE, Engelward BP
Environ Mol Mutagen. 2021 Feb;62(2):108-123. doi: 10.1002/em.22419
PMID: 33314311

            Voted ‘Paper of the Year’ in Environmental and Molecular Mutagenesis

Pentiptycene Polymer/Single-Walled Carbon Nanotube Complexes: Applications in Benzene, Toluene, and o-Xylene Detection
Luo SL, Lin CJ, Ku KH, Yoshinaga K, Swager TM
ACS Nano. 2020 Jun 23;14(6):7297-7307. doi: 10.1021/acsnano.0c02570
PMID: 32510203

The MIT superfund research program: studies on cleaning up genes and the environment 
Kay JE, Engelward BP
Scientia. 2020. doi: 10.33548/scientia480

Tackling chemically contaminated sites in the United States
Kay JE, Engelward BP
Open Access Government. 2020

Assessing the accuracy of low-cost optical particle sensors using a physics-based approach
Hagan DH, Kroll JH
Atmos Meas Tech. 2020;13(11):6343-6355. doi: 10.5194/amt-13-6343-2020 PMID: 33777248

SpheroidChip: Patterned Agarose Microwell Compartments Harboring HepG2 Spheroids are Compatible with Genotoxicity Testing
Chao C, Ngo Le P, Engelward BP
ACS Biomater Sci Eng. 2020 Apr 13;6(4):2427-2439. doi: 10.1021/acsbiomaterials.9b01951
PMID: 33145399
In the NIEHS Superfund Research Program News

Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates
Ngo LP, Owiti NA, Swartz C, Winters J, Su Y, Ge J, Xiong A, Han J, Recio L, Samson LD, Engelward BP
Nucleic Acids Res. 2020 Feb 20;48(3):e13. doi: 10.1093/nar/gkz1077
PMID: 31822921
MIT News. Screen could offer better safety tests for new chemicals
In the NIEHS Superfund Research Program News
NIEHS Paper of the Month

Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT
Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat M, Croy RG, Essigmann JM
Chem Res Toxicol. 2020 Feb 17;33(2):625-633. doi: 10.1021/acs.chemrestox.9b00444
PMID: 31841318

A Multi-Function Sensor for Eddy Correlation Measurements of Benthic Flux
Hu IH, Hemond HF
IEEE Sens J. 2020 Feb;20(3):1509-1526. doi: 10.1109/jsen.2019.2946968
PMID: 32158362

A global atmospheric chemistry model for the fate and transport of PFCAs and their precursors
Thackray CP, Selin NE, Young CJ
Environ Sci Process Impacts. 2020 Feb 1;22(2):285-293. doi: 10.1039/c9em00326f
PMID: 31942888

Vertical transport of sediment-associated metals and cyanobacteria by ebullition in a stratified lake
Delwiche K, Gu J, Hemond H, Preheim SP
Biogeosciences. 2020;17(12):3135-3147. doi: 10.5194/bg-2019-243
PMID: 33072161

Applications of CometChip for Environmental Health Studies
Chao C, Engelward BP
Chem Res Toxicol. 2020 Jul 20;33(7):1528-1538. doi: 10.1021/acs.chemrestox.9b00393
PMID: 32519858

Dimensionality-reduction techniques for complex mass spectrometric datasets: application to laboratory atmospheric organic oxidation experiments
Koss AR, Canagaratna MR, Zaytsev A, Krechmer JE, Breitenlechner M, Nihill KJ, Lim CY, Rowe JC, Roscioli JR, Keutsch FN, Kroll JH
Atmos Chem Phys. 2020;20(2):1021-1041. doi: 10.5194/acp-20-1021-2020
PMID: 33777125

Inflammation-induced DNA damage, mutations and cancer
Kay J, Thadhani E, Samson L, Engelward B
DNA Repair (Amst). 2019 Nov;83:102673. doi: 10.1016/j.dnarep.2019.102673
PMID: 31387777

Chapter 12: Tactile Approaches to Help Learners Visualize Key Processes in Environmental Health Sciences
Environmental Health Literacy 2019
Vandiver KM
Editors: Dr. Symma Finn and Liam R. O’Fallon. Springer. © The Author(s) 2019 315 S. Finn, L. R. O’Fallon. https://doi.org/10.1007/978-3-319-94108-0_12

Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells
Nagel ZD, Beharry AA, Mazzucato P, Kitange GJ, Sarkaria JN, Kool ET, Samson LD.PLoS One. 2019 Feb 27;14(2):e0208341. doi: 10.1371/journal.pone.0208341
PMID: 30811507

Chemiresistive Carbon Nanotube Sensors for N-Nitrosodialkylamines
He M, Croy RG, Essigmann JM, Swager TM
ACS Sens. 2019 Oct 25;4(10):2819-2824. doi: 10.1021/acssensors.9b01532
PMID: 31573183
c&en. Carbon nanotube sensor detects nitrosamines in the air

Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation
Ngo LP, Chan TK, Ge J, Samson LD, Engelward BP
Cell Rep. 2019 Feb 5;26(6):1668-1678.e4. doi: 10.1016/j.celrep.2019.01.053
PMID: 30726746
In the MIT News and on the MIT Homepage. A better way to measure cell survival
In the NIEHS Environmental Factor
NIEHS Paper of the Month

Introduction: Chemical Sensors
Swager TM, Mirica KA
Chem Rev. 2019 Jan 9;119(1):1-2. doi: 10.1021/acs.chemrev.8b00764
PMID: 30829042

Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2-/- Il10-/- gpt delta mice is influenced by sex
Ge Z, Feng Y, Sheh A, Muthupalani S, Gong G, Chawanthayatham S, Essigmann JM, Fox JG
Int J Cancer. 2019 Aug 15;145(4):1042-1054. doi: 10.1002/ijc.32332
PMID: 30977112

Carbon Nanotube Chemical Sensors
Schroeder V, Savagatrup S, He M, Lin S, Swager TM
Chem Rev. 2019 Jan 9;119(1):599-663. doi: 10.1021/acs.chemrev.8b00340
PMID: 30226055

Mechanistic study of the formation of ring-retaining and ring-opening products from the oxidation of aromatic compounds under urban atmospheric conditions
Zaytsev A, Koss AR, Breitenlechner M, Krechmer JE, Nihill KJ, Lim CY, Rowe JC, Cox JL, Moss J, Roscioli JR, Canagaratna MR, Worsnop DR, Kroll JH, Keutsch FN
Atmos Chem Phys. 2019;19(23):15117-15129. doi: 10.5194/acp-19-15117-2019
PMID: 32256548

Using collision-induced dissociation to constrain sensitivity of ammonia chemical ionization mass spectrometry ( NH4+ CIMS) to oxygenated volatile organic compounds
Zaytsev A, Breitenlechner M, Koss AR, Lim CY, Rowe JC, Kroll JH, Keutsch FN
Atmos Meas Tech. 2019;12(3):1861-1870. doi: 10.5194/amt-12-1861-2019
PMID: 32215111

A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth
Rothenberg DA, Taliaferro JM, Huber SM, Begley TJ, Dedon PC, White FM
iScience. 2018 Nov 30;9:367-381. doi: 10.1016/j.isci.2018.11.004
PMID: 30466063

Global and Local Impacts of Delayed Mercury Mitigation Efforts
Angot H, Hoffman N, Giang A, Thackray CP, Hendricks AN, Urban NR, Selin NE
Environ Sci Technol. 2018 Nov 20;52(22):12968-12977. doi: 10.1021/acs.est.8b04542
PMID: 30376303
EurekAlert. Study: Impact of mercury-controlling policies shrinks with every five-year delay

Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B1 as a case study
Fedeles BI, Essigmann JM
DNA Repair (Amst). 2018 Nov;71:12-22. doi: 10.1016/j.dnarep.2018.08.008
PMID: 30309820

Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice
Wadduwage DN, Kay J, Singh VR, Kiraly O, Sukup-Jackson MR, Rajapakse J, Engelward BP, So PTC
Sci Rep. 2018 Aug 14;8(1):12108. doi: 10.1038/s41598-018-30557-9
PMID: 30108260

Resistive and Capacitive γ-Ray Dosimeters Based On Triggered Depolymerization in Carbon Nanotube Composites
Zeininger L, He M, Hobson ST, Swager TM
ACS Sens. 2018 May 25;3(5):976-983. doi: 10.1021/acssensors.8b00108
PMID: 29558118

Chemical evolution of atmospheric organic carbon over multiple generations of oxidation
Isaacman-VanWertz G, Massoli P, O’Brien R, Lim C, Franklin JP, Moss JA, Hunter JF, Nowak JB, Canagaratna MR, Misztal PK, Arata C, Roscioli JR, Herndon ST, Onasch TB, Lambe AT, Jayne JT, Su L, Knopf DA, Goldstein AH, Worsnop DR, Kroll JH
Nat Chem. 2018 Apr;10(4):462-468. doi: 10.1038/s41557-018-0002-2
PMID: 29483638

Linking science and policy to support the implementation of the Minamata Convention on Mercury
Selin H, Keane SE, Wang S, Selin NE, Davis K, Bally D
Ambio. 2018 Mar;47(2):198-215. doi: 10.1007/s13280-017-1003-x
PMID: 29388129

A Prototype Sensor for In Situ Sensing of Fine Particulate Matter and Volatile Organic Compounds
Ng CL, Kai FM, Tee MH, Tan N, Hemond HF
Sensors (Basel). 2018 Jan 18;18(1):265. doi: 10.3390/s18010265
PMID: 29346281

Room temperature amine sensors enabled by sidewall functionalization of single-walled carbon nanotubes
Paoletti C, He M, Salvo P, Melai B, Calisi N, Mannini M, Cortigiani B, Bellagambi FG, Swager TM, Di Francesco F, Pucci A
RSC Adv. 2018;8(10):5578-5585. doi: 10.1039/C7RA13304A. Epub 2018 Feb 1
PMID: 30820317

Hyperstage Graphite: Electrochemical Synthesis and Spontaneous Reactive Exfoliation
Jeon I, Yoon B, He M, Swager TM
Adv Mater. 2018 Jan;30(3):10.1002/adma.201704538. doi: 10.1002/adma.201704538
PMID: 29194799

Bio-Inspired Carbon Monoxide Sensors with Voltage-Activated Sensitivity
Savagatrup S, Schroeder V, He X, Lin S, He M, Yassine O, Salama KN, Zhang XX, Swager TM
Angew Chem Int Ed Engl. 2017 Nov 6;56(45):14066-14070. doi: 10.1002/anie.201707491
PMID: 28952172

Early Detection of the Aflatoxin B1 Mutational Fingerprint: A Diagnostic Tool for Liver Cancer
Fedeles BI, Chawanthayatham S, Croy RG, Wogan GN, Essigmann JM
Mol Cell Oncol. 2017 May 19;4(4):e1329693. doi: 10.1080/23723556.2017.1329693
PMID: 28868344

Mutational Spectra of Aflatoxin B1 In Vivo Establish Biomarkers of Exposure for Human Hepatocellular Carcinoma
Chawanthayatham S, Valentine CC 3rd, Fedeles BI, Fox EJ, Loeb LA, Levine SS, Slocum SL, Wogan GN, Croy RG, Essigmann JM
Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3101-E3109. doi: 10.1073/pnas.1700759114
PMID: 28351974
MIT News. Detecting mutations could lead to earlier liver cancer diagnosis