Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents
Armijo AL, Thongararm P, Fedeles BI, Yau J, Kay JE, Corrigan JJ, Chancharoen M, Chawanthayatham S, Samson LD, Carrasco SE, Engelward BP, Fox JG, Croy RG, Essigmann JM. NAR Cancer 2023 Mar 27;5(2):zcad015. doi: 10.1093/narcan/zcad015. eCollection 2023 Jun. PMID: 36992846 [PubMed]

Interaction of N-nitrosamines with binuclear copper complexes for luminescent detection
Feng H, Luo SL, Croy RG, Essigmann JM, Swager TM. Dalton Trans 2023 Mar 7;52(10):3219-3233. doi: 10.1039/d2dt03848j. PMID: 36799554 [PubMed]

Improved Procedures for the Synthesis of 9,9-Disubstituted 9,10,-Dihydroacridines
Beard, J. C.; Swager, T.M. J Org Chem 2023 Feb 3;88(3):1918-1921. doi: 10.1021/acs.joc.2c03004. Epub 2023 Jan 20. PMID: 36661076 [PubMed]

Assessing Regional Sources of Atmospheric Polycyclic Atmospheric Hydrocarbon Pollution and Associated Human Cancer Risk (2023)
Disha Trivedi. Master’s Thesis Technology and Policy

Measuring DNA modifications with the comet assay: a compendium of protocols
Collins A, Møller P, Gajski G, Vodenková S, Abdulwahed A, Anderson D, Bankoglu EE, Bonassi S, Boutet-Robinet E, Brunborg G, Chao C, Cooke MS, Costa C, Costa S, Dhawan A, de Lapuente J, Bo' CD, Dubus J, Dusinska M, Duthie SJ, Yamani NE, Engelward B, Gaivão I, Giovannelli L, Godschalk R, Guilherme S, Gutzkow KB, Habas K, Hernández A, Herrero O, Isidori M, Jha AN, Knasmüller S, Kooter IM, Koppen G, Kruszewski M, Ladeira C, Laffon B, Larramendy M, Hégarat LL, Lewies A, Lewinska A, Liwszyc GE, de Cerain AL, Manjanatha M, Marcos R, Milić M, de Andrade VM, Moretti M, Muruzabal D, Novak M, Oliveira R, Olsen AK, Owiti N, Pacheco M, Pandey AK, Pfuhler S, Pourrut B, Reisinger K, Rojas E, Rundén-Pran E, Sanz-Serrano J, Shaposhnikov S, Sipinen V, Smeets K, Stopper H, Teixeira JP, Valdiglesias V, Valverde M, van Acker F, van Schooten FJ, Vasquez M, Wentzel JF, Wnuk M, Wouters A, Žegura B, Zikmund T, Langie SAS, Azqueta A. Nature Protoc 2023 Jan 27. doi: 10.1038/s41596-022-00754-y. Online ahead of print. PMID: 36707722 DOI: 10.1038/s41596-022-00754-y [PubMed]

Porous Polymers Containing Metallocalix[4]arene for Extraction of Tobacco-Specific Nitrosamines
Lu, R.-Q., Yuan, W.; Luo, S.-X. L.; Wu, Y.-C. M.; Etkind, S. I.; Kumar, M.; Swager, T. M. Chem. Mater 2022 Nov, 34, 23, 10623–10630

Transgenic mice harboring direct repeat substrates reveal key underlying causes of homologous recombination in vivo
Moise AC, Kay JE, Engelward BP. DNA Repair (Amst) 2022 Oct 10;120:103419. doi: 10.1016/j.dnarep.2022.103419. Epub ahead of print. PMID: 36257175 [PubMed]

Novel In Vivo CometChip Reveals NDMA-Induced DNA Damage and Repair in Multiple Mouse Tissues
Owiti NA, Corrigan JJ, Pribyl LJ, Kay JE, Engelward BP. Int J Mol Sci 2022 Oct 4;23(19):11776. doi: 10.3390/ijms231911776. PMID: 36233095 [PubMed]

Establishing linkages among DNA damage, mutagenesis, and genetic diseases
Basu AK, Essigmann JM. Chem Res Toxicol 2022 Oct 17;35(10):1655-1675. doi: 10.1021/acs.chemrestox.2c00155. Epub 2022 Jul 26. PMID: 35881568 Review [PubMed]

Integrated genotoxicity testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip® assay in TK6 cells
Buick JK, Rowan-Carroll A, Gagné R, Williams A, Chen R, Li HH, Fornace AJ Jr, Chao C, Engelward BP, Frötschl R, Ellinger-Ziegelbauer H, Pettit SD, Aubrecht J, Yauk CL. Front. Toxicol 2022 Sep 23;4:991590. doi: 10.3389/ftox.2022.991590. eCollection 2022

There’s Something in the Water: N-nitrosodimethylamine
Engelward B. Scientia 2022 July 01. DOI:

Using the HepaCometChip assay for broad-spectrum DNA damage analysis
Owiti NA, Kaushal S, Martin L, Sly J, Swartz CD, Fowler J, Corrigan JJ, Recio L, Engelward BP. Curr Protoc 2022 Sep;2(9):e563. doi: 10.1002/cpz1.563. PubMed PMID: 36165707; PubMed Central PMCID: PMC9522315 [PubMed]

NExtSEEK: extending SEEK for active management of interoperable metadata
Pradhan D, Ding H, Zhu J, Engelward BP, Levine SS. J Biomol Tech 2022 Feb 2;33(1):3fc1f5fe.db404124. doi: 10.7171/3fc1f5fe.db404124. eCollection 2022 Apr 15. PMID: 35836998 [PubMed]

Using the HepaCometChip Assay for Broad-Spectrum DNA Damage Analysis
Owiti NA, Kaushal S, Martin L, Sly J, Swartz CD, Fowler J, Corrigan JJ, Recio L, Engelward BP. Current Protocols 2022 September;2(9):e563. PubMed PMID: 36165707; PubMed Central PMCID: PMC9522315; DOI: 10.1002/cpz1.563 [PubMed]

The Parallel Transformations of Polycyclic Aromatic Hydrocarbons in the Body and in the Atmosphere
Hrdina AIH, Kohale IN, Kaushal S, Kelly J, Selin NE, Engelward BP, Kroll JH. Environmental health perspectives 2022 February;130(2):25004. PubMed PMID: 35225689; PubMed Central PMCID: PMC8884122; DOI: 10.1289/EHP9984 [PubMed]

Building Environmental Health and Genomics Literacy among Healthcare Providers Serving Vulnerable Communities: An Innovative Educational Framework.
Vandiver KM, Erdei E, Mayer AG, Ricciardi C, O'Leary M, Burke K, Zelikoff JT. Building Environmental Health and Genomics Literacy among Healthcare Providers Serving Vulnerable Communities: An Innovative Educational Framework. International journal of environmental research and public health. 2022 January 14;19(2). PubMed PMID: 35055751; PubMed Central PMCID: PMC8776035; DOI: 10.3390/ijerph19020929.. International journal of environmental research and public health 2022 January 14;19(2). PubMed PMID: 35055751; PubMed Central PMCID: PMC8776035; DOI: 10.3390/ijerph19020929 [PubMed]

Global Cancer Risk From Unregulated Polycyclic Aromatic Hydrocarbons
Kelly JM, Ivatt PD, Evans MJ, Kroll JH, Hrdina AIH, Kohale IN, White FM, Engelward BP, Selin NE. Geohealth 2021 Sep 1;5(9):e2021GH000401 PMID: 34589640 doi: 10.1029/2021GH000401 [PubMed]

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Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice
Kay JE, Corrigan JJ, Armijo AL, Nazari IS, Kohale IN, Torous DK, Avlasevich SL, Croy RG, Wadduwage DN, Carrasco SE, Dertinger SD, White FM, Essigmann JM, Samson LD, Engelward BP. Cell Rep 2021 Mar 16;34(11):108864 PMID: 33730582 doi: 10.1016/j.celrep.2021.108864 [PubMed]

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Segev T, Harvey AP, Ajmani A, Johnson C, Longfellow W, Vandiver KM, Hemond H. Environ Res 2021 Jan;192:110460 PMID: 33217437 doi: 10.1016/j.envres.2020.110460 [PubMed]

An Organic Chemist’s Guide to N-Nitrosamines: Their Structure, Reactivity, and Role as Contaminants
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Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks
Kohale IN, Burgenske DM, Mladek AC, Bakken KK, Kuang J, Boughey JC, Wang L, Carter JM, Haura EB, Goetz MP, Sarkaria JN, White FM. Cancer Res 2021 Jul 15;81(14):3930-3941 PMID: 34016623 doi: 10.1158/0008-5472.CAN-21-0214 [PubMed]

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CometChip enables parallel analysis of multiple DNA repair activities
Ge J, Ngo LP, Kaushal S, Tay IJ, Thadhani E, Kay JE, Mazzucato P, Chow DN, Fessler JL, Weingeist DM, Sobol RW, Samson LD, Floyd SR, Engelward BP. DNA Repair (Amst) 2021 Oct;106:103176 PMID: 34365116 doi: 10.1016/j.dnarep.2021.103176 [PubMed]

Andrographolide, an Antioxidant, Counteracts Paraquat- Induced Mutagenesis in Mammalian Cells
Tajai P, Suriyo T, Rangkadilok N, Fedeles B, Essigmann JM, Satayavivad J. Asian Pac J Cancer Prev 2021 Feb 1;22(S1):3-8 PMID: 33576206 doi: 10.31557/APJCP.2021.22.S1.3 [PubMed]

CometChip analysis of human primary lymphocytes enables quantification of inter-individual differences in the kinetics of repair of oxidative DNA damage
Ngo LP, Kaushal S, Chaim IA, Mazzucato P, Ricciardi C, Samson LD, Nagel ZD, Engelward BP. Free Radic Biol Med 2021 Oct;174:89-99 PMID: 34324980 doi: 10.1016/j.freeradbiomed.2021.07.033 [PubMed]

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High-Density, Targeted Monitoring of Tyrosine Phosphorylation Reveals Activated Signaling Networks in Human Tumors
Stopfer LE, Flower CT, Gajadhar AS, Patel B, Gallien S, Lopez-Ferrer D, White FM. Cancer Res 2021 May 1;81(9):2495-2509 PMID: 33509940 doi: 10.1158/0008-5472.CAN-20-3804 [PubMed]

A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures
Buick JK, Williams A, Meier MJ, Swartz CD, Recio L, Gagné R, Ferguson SS, Engelward BP, Yauk CL. Front Public Health 2021 Aug 18;9:694834 PMID: 34485225 doi: 10.3389/fpubh.2021.694834 [PubMed]

Fluorescence Sheds Light on DNA Damage, DNA Repair, and Mutations
Owiti NA, Nagel ZD, Engelward BP. Trends Cancer 2021 Mar;7(3):240-248 PMID: 33203608 doi: 10.1016/j.trecan.2020.10.006 [PubMed]

Analysis of mutations in tumor and normal adjacent tissue via fluorescence detection
Kay JE, Mirabal S, Briley WE, Kimoto T, Poutahidis T, Ragan T, So PT, Wadduwage DN, Erdman SE, Engelward BP. Environ Mol Mutagen 2021 Feb;62(2):108-123 PMID: 33314311 doi: 10.1002/em.22419 [PubMed]

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Implications of an epidemiological study showing an association between in utero NDMA exposure and childhood cancer
Engelward BP. Environ Mol Mutagen 2021 Jun;62(5):288-292 PMID: 33963777 doi: 10.1002/em.22434 [PubMed]

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Pentiptycene Polymer/Single-Walled Carbon Nanotube Complexes: Applications in Benzene, Toluene, and o-Xylene Detection
Luo SL, Lin CJ, Ku KH, Yoshinaga K, Swager TM. ACS Nano 2020 Jun 23;14(6):7297-7307 PMID: 32510203 doi: 10.1021/acsnano.0c02570 [PubMed]

The MIT superfund research program: studies on cleaning up genes and the environment
Kay JE, Engelward BP. Scientia 2020 doi: 10.33548/scientia480

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Tackling chemically contaminated sites in the United States
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Assessing the accuracy of low-cost optical particle sensors using a physics-based approach
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SpheroidChip: Patterned Agarose Microwell Compartments Harboring HepG2 Spheroids are Compatible with Genotoxicity Testing
Chao C, Ngo Le P, Engelward BP. ACS Biomater Sci Eng 2020 Apr 13;6(4):2427-2439 PMID: 33145399 doi: 10.1021/acsbiomaterials.9b01951 [PubMed]

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Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates
Ngo LP, Owiti NA, Swartz C, Winters J, Su Y, Ge J, Xiong A, Han J, Recio L, Samson LD, Engelward BP. Nucleic Acids Res 2020 Feb 20;48(3):e13 PMID: 31822921 doi: 10.1093/nar/gkz1077 [PubMed]

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Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT
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A Multi-Function Sensor for Eddy Correlation Measurements of Benthic Flux
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A global atmospheric chemistry model for the fate and transport of PFCAs and their precursors
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Vertical transport of sediment-associated metals and cyanobacteria by ebullition in a stratified lake
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Applications of CometChip for Environmental Health Studies
Chao C, Engelward BP. Chem Res Toxicol 2020 Jul 20;33(7):1528-1538 PMID: 32519858 doi: 10.1021/acs.chemrestox.9b00393 [PubMed]

Dimensionality-reduction techniques for complex mass spectrometric datasets: application to laboratory atmospheric organic oxidation experiments
Koss AR, Canagaratna MR, Zaytsev A, Krechmer JE, Breitenlechner M, Nihill KJ, Lim CY, Rowe JC, Roscioli JR, Keutsch FN, Kroll JH. Atmos Chem Phys 2020;20(2):1021-1041 PMID: 33777125 doi: 10.5194/acp-20-1021-2020 [PubMed]

Inflammation-induced DNA damage, mutations and cancer
Kay J, Thadhani E, Samson L, Engelward B. DNA Repair (Amst) 2019 Nov;83:102673 PMID: 31387777 doi: 10.1016/j.dnarep.2019.102673 [PubMed]

Chapter 12: Tactile Approaches to Help Learners Visualize Key Processes in Environmental Health Sciences
Vandiver KM. Environmental Health Literacy Editors: Dr. Symma Finn and Liam R. O'Fallon. Springer. © The Author(s) 2019 315 S. Finn, L. R. O’Fallon. [Other Article]

Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells
Nagel ZD, Beharry AA, Mazzucato P, Kitange GJ, Sarkaria JN, Kool ET, Samson LD.. PloS One 2019 Feb 27;14(2):e0208341. PMID: 30811507 doi: 10.1371/journal.pone.0208341 [PubMed]

Chemiresistive Carbon Nanotube Sensors for N-Nitrosodialkylamines
He M, Croy RG, Essigmann JM, Swager TM. ACS Sens 2019 Oct 25;4(10):2819-2824 PMID: 31573183 doi: 10.1021/acssensors.9b01532 [PubMed]

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Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation
Ngo LP, Chan TK, Ge J, Samson LD, Engelward BP. Cell Rep 2019 Feb 5;26(6):1668-1678.e4 PMID: 30726746 doi: 10.1016/j.celrep.2019.01.053 [PubMed]

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Introduction: Chemical Sensors
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Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2-/- Il10-/- gpt delta mice is influenced by sex
Ge Z, Feng Y, Sheh A, Muthupalani S, Gong G, Chawanthayatham S, Essigmann JM, Fox JG. Int J Cancer 2019 Aug 15;145(4):1042-1054 PMID: 30977112 doi: 10.1002/ijc.32332 [PubMed]

Carbon Nanotube Chemical Sensors
Schroeder V, Savagatrup S, He M, Lin S, Swager TM. Chem Rev 2019 Jan 9;119(1):599-663 PMID: 30226055 doi: 10.1021/acs.chemrev.8b00340 [PubMed]

Mechanistic study of the formation of ring-retaining and ring-opening products from the oxidation of aromatic compounds under urban atmospheric conditions
Zaytsev A, Koss AR, Breitenlechner M, Krechmer JE, Nihill KJ, Lim CY, Rowe JC, Cox JL, Moss J, Roscioli JR, Canagaratna MR, Worsnop DR, Kroll JH, Keutsch FN. Atmos Chem Phys 2019;19(23):15117-15129 PMID: 32256548 doi: 10.5194/acp-19-15117-2019 [PubMed]

Using collision-induced dissociation to constrain sensitivity of ammonia chemical ionization mass spectrometry ( NH4+ CIMS) to oxygenated volatile organic compounds
Zaytsev A, Breitenlechner M, Koss AR, Lim CY, Rowe JC, Kroll JH, Keutsch FN. Atmos Meas Tech 2019;12(3):1861-1870 PMID: 32215111 doi: 10.5194/amt-12-1861-2019 [PubMed]

A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth
Rothenberg DA, Taliaferro JM, Huber SM, Begley TJ, Dedon PC, White FM. iScience 2018 Nov 30;9:367-381 PMID: 30466063 doi: 10.1016/j.isci.2018.11.004 [PubMed]

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Global and Local Impacts of Delayed Mercury Mitigation Efforts
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Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B1 as a case study
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Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice
Wadduwage DN, Kay J, Singh VR, Kiraly O, Sukup-Jackson MR, Rajapakse J, Engelward BP, So PTC. Sci Rep 2018 Aug 14;8(1):12108 PMID: 30108260 doi: 10.1038/s41598-018-30557-9 [PubMed]

Resistive and Capacitive γ-Ray Dosimeters Based On Triggered Depolymerization in Carbon Nanotube Composites
Zeininger L, He M, Hobson ST, Swager TM. ACS Sens 2018 May 25;3(5):976-983 PMID: 29558118 doi: 10.1021/acssensors.8b00108 [PubMed]

Chemical evolution of atmospheric organic carbon over multiple generations of oxidation
Isaacman-VanWertz G, Massoli P, O’Brien R, Lim C, Franklin JP, Moss JA, Hunter JF, Nowak JB, Canagaratna MR, Misztal PK, Arata C, Roscioli JR, Herndon ST, Onasch TB, Lambe AT, Jayne JT, Su L, Knopf DA, Goldstein AH, Worsnop DR, Kroll JH. Nat Chem 2018 Apr;10(4):462-468 PMID: 29483638 doi: 10.1038/s41557-018-0002-2 [PubMed]

Linking science and policy to support the implementation of the Minamata Convention on Mercury
Selin H, Keane SE, Wang S, Selin NE, Davis K, Bally D. Ambio 2018 Mar;47(2):198-215 PMID: 29388129 doi: 10.1007/s13280-017-1003-x [PubMed]

A Prototype Sensor for In Situ Sensing of Fine Particulate Matter and Volatile Organic Compounds
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Room temperature amine sensors enabled by sidewall functionalization of single-walled carbon nanotubes
Paoletti C, He M, Salvo P, Melai B, Calisi N, Mannini M, Cortigiani B, Bellagambi FG, Swager TM, Di Francesco F, Pucci A. RSC Adv 2018;8(10):5578-5585 PMID: 30820317 doi: 10.1039/C7RA13304A Epub 2018 Feb 1 [PubMed]

Hyperstage Graphite: Electrochemical Synthesis and Spontaneous Reactive Exfoliation
Jeon I, Yoon B, He M, Swager TM. Adv Mater 2018 Jan;30(3):10.1002/adma.201704538 PMID: 29194799 doi: 10.1002/adma.201704538 [PubMed]

Bio-Inspired Carbon Monoxide Sensors with Voltage-Activated Sensitivity
Savagatrup S, Schroeder V, He X, Lin S, He M, Yassine O, Salama KN, Zhang XX, Swager TM. Angew Chem Int Ed Engl 2017 Nov 6;56(45):14066-14070 PMID: 28952172 doi: 10.1002/anie.201707491 [PubMed]

Early Detection of the Aflatoxin B1 Mutational Fingerprint: A Diagnostic Tool for Liver Cancer
Fedeles BI, Chawanthayatham S, Croy RG, Wogan GN, Essigmann JM. Mol Cell Oncol 2017 May 19;4(4):e1329693 PMID: 28868344 doi: 10.1080/23723556.2017.1329693 [PubMed]

Mutational Spectra of Aflatoxin B1 In Vivo Establish Biomarkers of Exposure for Human Hepatocellular Carcinoma
Chawanthayatham S, Valentine CC 3rd, Fedeles BI, Fox EJ, Loeb LA, Levine SS, Slocum SL, Wogan GN, Croy RG, Essigmann JM. Proc Natl Acad Sci U S A 2017 Apr 11;114(15):E3101-E3109 PMID: 28351974 doi: 10.1073/pnas.1700759114 [PubMed]

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