April 30, 2021

By Bevin P. Engelward

The Olin Chemical Superfund Site in Wilmington, MA, contains high levels of NDMA, a probable human carcinogen that traveled nearly a mile underground, contaminating town wells that had been used by thousands of people. After the discovery of a childhood cancer cluster, the Massachusetts Department of Public Health did…

July 14, 2020

By Bevin P. Engelward

Program Director Prof. Bevin Engelward and RTC leader Dr. Jenny Kay collaborated with editors of the science outreach journal Scientia to produce an article about the MIT SRP and its biological research projects. The article describes the NIEHS Superfund Research Program and MIT SRP’s chemicals of interest, N-nitrosamines, probable human carcinogens t…

July 14, 2020

By Bevin P. Engelward

Cell survival assays are routine in many life science laboratories, yet direct measurements of cell growth are rarely performed due to the fact that the gold standard colony forming assay is slow and laborious. A novel adaptation to the traditional colony forming assay was developed by Postdoc Lizzie Ngo of the…

July 14, 2020

By Bevin P. Engelward

A team led by CEC Director Dr. Kathy Vandiver won the Norman B. Leventhal City Prize, a $100,000 award offered by MIT’s Leventhal Center. The objective of the ‘Malden River Works for Waterfront Equity and Resilience’ project is to create a public open space to improve opportunities for community recreation and…

July 14, 2020

By Bevin P. Engelward

A group of Superfund Research Program Center leaders from MIT, Northeastern University, University of Kentucky, and Louisiana State University went to Washington DC to engage with Professional Staff from the House and Senate Appropriations Committees. Led by Prof Akram Alshawabkeh of Northeastern, the objective of the meetings was to share…

July 14, 2020

By Bevin P. Engelward

A blind spot for high throughput genotoxicity assays is the inability to detect bulky lesions on DNA that have the potential to be carcinogenic. To overcome this limitation, Drs. Lizzie Ngo and Norah Owiti from the Engelward laboratory developed new methodologies for the CometChip, a high throughput comet assay…

July 14, 2020

By Bevin P. Engelward

Amanda Armijo, a postdoctoral fellow at MIT Professor John Essigmann’s group in the Department of Biological Engineering and Dr. James Fox’s group in the Division of Comparative Medicine, is studying the genotoxic signatures caused by environmental contaminants and how these mutations result in development of liver cancer. Specifically, her…

July 14, 2020

By Bevin P. Engelward

There is much interest in understanding the mechanisms underlying the complex patterns displayed in mutational spectra, because these spectra will help to illuminate the molecular etiology of genetic diseases, such as cancer. The lambda gpt delta C57BL/6J mouse is an extraordinarily useful model for the probing underlying mechanisms of human cancer, and the…

July 14, 2020

By Bevin P. Engelward

On August 2, 2019, a team from MIT SRP visited stakeholders in Maine, including A.E. Hodsdon Consulting Engineers in Waterville, ME, the group that oversees the drinking water treatment facility for the Passamaquoddy Tribe at Pleasant Point. The district is known as the Passamaquoddy Water District (PWD) and facility’s…

July 14, 2020

By Bevin P. Engelward

With support from the NIEHS, MIT SRP is developing new infrastructure that enables data to be combined in new ways and that ensures FAIR practices. An exciting development is the ability to upload metadata in real time for wide ranging data sets, including environmental as well as biological data. The new…